Fibrinogen replacement therapies
  Fresh Frozen Plasma (FFP) 1-2 Cryoprecipitate (Cryo) 1-2 RiaSTAP
Fibrinogen content per unit volume ~500 mg per 250 mL ≥150 mg per 5-20 mL ~900-1300 mg per 50 mL
Fibrinogen content per mL ~2 mg per mL ≥10 mg per mL ~20 mg per mL
Exact fibrinogen content per unit Unknown Unknown Listed on vial label
Thawing required Yes Yes No
ABO matching required Yes Yes No
Virus inactivation/removal No No Yes
Shelf life 12 months (frozen) 12 months (frozen) up to 60 months (room temperature)
  • RiaSTAP has the highest fibrinogen content per mL
  • Each vial of RiaSTAP is clearly labeled with the exact fibrinogen content to assist with coagulation management
  • Virus inactivation/removal reduces risk of exposure to infectious agents
  • The risk of virus transmission cannot be completely eliminated
  • Long shelf-life maximizes accessibility

The comparable safety and efficacy of these products have not been established in head-to-head clinical trials.

  1. Blood Centers of America. Blood Products. http://www.bca-hemerica.com/products-services/blood-products/ Accessed September 19, 2016.
  2. American Association of Blood Banks, America's Blood Centers, American Red Cross. Circular of Information for the Use of Human Blood and Blood Components. Bethesda, MD: American Association of Blood Banks, 2013.

Important Safety Information

RiaSTAP®, Fibrinogen Concentrate (Human), is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.

RiaSTAP is contraindicated in patients with known anaphylactic or severe systemic reactions to human plasma-derived products.

Monitor patients for early signs of anaphylaxis or hypersensitivity reactions and if necessary, discontinue administration and institute appropriate treatment. Thrombotic events have been reported in patients receiving RiaSTAP; weigh the benefits of administration versus the risks of thrombosis.

RiaSTAP is made from pooled human plasma. Products made from human plasma may contain infectious agents, eg, viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most serious adverse reactions observed are thrombotic episodes (pulmonary embolism, myocardial infarction, deep vein thrombosis) and anaphylactic reactions. The most common adverse reactions observed in clinical studies (frequency >1%) were fever and headache.

Please see full prescribing information for RiaSTAP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.